Cristina, back from her honeymoon trip, searches in vain for Burke; Meredith, Cristina, Izzie and Alex spend their first day as residents with their own groups of interns.
Meredith's friends and fellow doctors work to save her life after her near-drowning; Izzie gathers her courage to perform surgery at the site of the ferry accident.
Derek and Meredith get ready for their wedding; college students injured in a car accident are admitted to the ER; Izzie starts experiencing familiar symptoms.
While undergoing aggressive cancer treatment, Izzie focuses on planning Meredith and Derek's wedding; Callie's father visits; Owen seeks help with his PTSD.
Abruzzi's demotion puts the entire escape-plan at risk; if Michael protects the new inmate, T-Bag threatens to expose the plan to the guards.