Cristina, back from her honeymoon trip, searches in vain for Burke; Meredith, Cristina, Izzie and Alex spend their first day as residents with their own groups of interns.
Castle and Beckett are thrust into New York's raucous music industry as they investigate the murder of an up-and-coming DJ; Esposito takes a troubled teen under his wing.
Ravi enlists the help of LA Clippers star Chris Paul so that he can play in Luke's basketball game; Jessie is forced to partner with Hudson for an assignment.
Vanessa plays matchmaker for Eve and sets her up with one of her students – not realizing Eve may already be going out with someone else. Meanwhile, Mike and Chuck suspect Eve is secretly dating Chuck’s son, Brandon.
Kirby and his friends are excited that they're finally old enough to attend the annual Forest Hills Ninth Annual Fright Night Film Festival.