P.D. Mani

The interns deal with a family involved in a car accident, Derek lets his emotions get the best of him, and Burke and Izzie make a new suggestion to Denny.

J.D. (Zach Braff) is frustrated when his budding romance with an ex-patient (guest star Elizabeth Bogush, "Titans") wilts as their dates are constantly interrupted by emergency calls. Meanwhile, Dr. Kelso (Ken Jenkins) becomes less fearsome to the wide-eyed interns when Dr. Cox (John C. McGinley) informs them how to avoid the blowhard's bite. In addition, a perplexed Carla (Judy Reyes) and Turk (Donald Faison) deal with their first sexual intimacy complication. Sarah Chalke also stars.

When Turk (Donald Faison) always seems occupied with new girlfriend Carla (Judy Reyes) and with work, a resentful J.D. (Zach Braff) feels like an odd-man-out and abandoned by his buddy -- especially when he believes that Turk botched a patient's surgery that could also implicate him for not reporting the mistake. In addition, J.D. is even more distracted by his tempting flirtations with Elliot (Sarah Chalke) but he feels that unless he makes a more serious romantic maneuver within 48 hours, their budding relationship will be forever doomed and downgraded to merely "friends" status. Elsewhere, Elliot seeks advice from a resentful Dr. Cox (John C. McGinley) who hardly relishes becoming the interns' designated mentor. Ken Jenkins also stars.

When J.D. (Zach Braff) accidentally gets stuck with a needle that may have been infected with hepatitis, he starts to shy away from dealing with his sicker patients. Meanwhile, he and Elliot (Sarah Chalke) are forced to deal with four doctors (guest stars Ed Begley, Jr., William Daniels, Stephen Furst and Eric Laneuville of "St. Elsewhere") who become ill while attending a local medical convention. Elsewhere, Turk (Donald Faison) pays a high price when he goes to Dr. Cox (John C. McGinley) to help him get in shape. Ken Jenkins and Judy Reyes also star.

The members of Oceanic 6 discover how to get back to the island, but not all of them want to return.

Vaughn learns of the PRF ambush on Sydney, Jack and Irina.