The doctors vie for a new position; Meredith struggles to stay focused; Maggie finds herself the keeper of a big secret; Amelia and Owen try to figure out their relationship; Jo and Alex's honeymoon doesn't go as planned.
Meredith treats a patient who happens to specialize in matchmaking; a seemingly drunk patient pushes Richard's buttons and gives him a medical mystery to solve; Maggie tries to reach Teddy after bearing the burden of her secret becomes overwhelming.
Things do not go as planned at Alex and Jo's wedding; the stress from the past year has taken a toll on Bailey, making her re-evaluate some of her decisions.
Alex and Jo go on a road trip to Iowa to find Alex's mom; Meredith gives a presentation on her mini-livers project, which attracts a lot of attention.
Arizona shares some cookies that, unbeknownst to her, contain a special ingredient; Catherine reveals some shocking details to Jackson; Jo comes into the surgical room at mid-operation of a major surgery.
