Jackson must focus on the groundbreaking surgery he has scheduled with Catherine and Richard; Jo assists Bailey with a patient who used to be an astronaut.
Meredith debates how to handle an unexpected situation in her personal life; Richard has an untimely reunion with an old friend; Jo has a hard time at work; Owen tries therapy.
Seattle firefighters Ben Warren and Andy Herrera head to Grey Sloan after rescuing two boys who were injured in a house fire; the doctors work on their projects for the surgical innovation contest; Amelia brings Tom Koracick in to consult.
Patients flood the hospital after gunfire goes off at a parade; a blast from the past throws Maggie off her game on the same day that Meredith tries to talk to her about dating Deluca; Owen and Amelia get some potentially life-altering news.
Alex tries desperately to save his patient while he waits for a severely agoraphobic blood donor to arrive from London; Jo reveals to Meredith why she's been so down.