Meredith believes she may have erred during surgery and endangered her career; nothing goes as planned for Izzie, who tries to throw a party for her new boyfriend.
Alex works hard to gain the trust of Annie, a shy patient with a gargantuan tumor, only to make a fool of himself in front of her later.
Meredith becomes disenchanted with her ignorance of parts of Derek's life; Alex treats a patient whose religious beliefs jeopardize her chances for recovery; a 40-year-old pregnant woman with cancer disagrees with Cristina's advice.
A male patient who seems to have a hysterical pregnancy fascinates the staff.
The men of Seattle Grace go on a camping trip; Addison and Callie must team up to work on a patient; Meredith assists with a procedure Sloan has never experienced; Bailey confronts Cristina, suspicious of her recent actions.