When FBI Agent Audrey Parker is called to Haven on a routine case, she finds her assignment has been killed in unexplainable fashion – and when strange weather phenomena begin to strike the town – and Audrey – she begins to suspect that not everything is as it seems in Haven. As the weather events grow more destructive, Audrey discovers that someone in town might be more connected to the incidents than she could possibly imagine – that Haven turns out to be a longtime refuge for people that are affected by a range of supernatural afflictions…

Audrey remains in Haven to follow up on a clue to her own orphan past – an old photo from the local newspaper, of the infamous "Colorado Kid" crime scene, reveals a woman who could be her mother. But when she helps Nathan investigate the seemingly random dangerous acts around town, Audrey herself is targeted – and they must race to figure what the connection could be, and what or who might be making them happen.

Audrey and Nathan investigate an upheaval at the local psychiatric hospital – where something happened to make the patients normal for a time, but sent their doctor into madness. As they track down the escaped patients, Audrey and Nathan discover that whatever caused the temporary reversal has begun to spill across all of Haven – making normal townspeople go dangerously insane.

While Audrey tries to settle in as a Haven local and as a new police officer in town, she stumbles upon another mysterious event in town, when food, fields, and even livestock around Haven all begin to die, and she joins with Nathan to investigate what the source of the epidemic could be – and what’s really happening in this extraordinary place.

When extremely old man mysteriously turn up dead in town – and appear to be aging and decomposing at an extraordinary rate – Audrey and Nathan begin to track down whatever must be preying upon the men of Haven. And when someone close to Audrey becomes the next victim, she must figure out how to reverse the process before it’s too late.

When local hunters in Haven begin to die from what appear to be animal attacks that defy explanation, Audrey and Nathan begin to suspect that area animals have turned the tables on their killers – hunting the hunters for a change. But Audrey and Nathan soon discover that even the animals in Haven are full of surprises.