A man takes control of an 18-wheeler semi-truck and leads police on a deadly game of cat and mouse while holding his wife at knifepoint; in Michigan, U.S. marshals must bring in a suspect wanted for the cold-blooded murder of his girlfriend.

An argument escalates into a double kidnapping, spurring a police chase; the suspect uses a hostage as a human shield and escapes into a nearby forest; what starts as a routine shoplifting case soon becomes something more bizarre.

A homicide suspect holding his own cousin hostage leads police on a chase through the city; a rookie cop chases a car acting strangely deep into a Florida swamp.

When a stolen vehicle hits and kills a veteran officer, it takes a massive manhunt to bring the criminals down; an officer in South Carolina learns that three bank robbers are coming his way and they do not intend to surrender quietly.

A man shoots two officers serving eviction papers and then escapes, sparking a high-speed car chase; two robbery suspects flee in a U-Haul truck; with one of the county's busiest intersections fast approaching, police must make a terrifying decision.