Cristina and Burke's wedding day arrives; the interns get their exam results; the chief's successor; Callie and George make a decision about their relationship.
The interns take their first-year medical exams; the residents attend to three injured mountain-climbers; Callie's suspicions of George and Izzie grow; Cristina struggles to write her wedding vows.
Morgan's visit with a survivor of unusual stabbings in upstate New York leads to more questions about the case.
House's former bandmate, Crandall, brings in a teenage girl who is having hallucinations about Hurricane Katrina; Cuddy looks for a sperm donor.
A sexy insurance investigator (Kristin Lehman) with a secret helps Castle and Beckett when a valuable sculpture is stolen and someone is murdered; a rich museum benefactor (Jessica Tuck) garners suspicion.