When a prominent member of Visualize is mysteriously killed, Jane investigates in the hopes that the case will provide a clue that will lead him to Red John.
House makes a shocking revelation in a bid to save himself from jail time; a firefighter chooses to have a risky, radical treatment on his brain in order to keep a secret.
Ross juggles duties and patients on Halloween; the new ER chief (Philip Casnoff) offends staffers; a schizophrenic (Sheila Kelley) says she is pregnant.
While researching unsolved killings in which the victims' organs were removed, Mulder uncovers a species-altering experiment that may be traced back to his own father.