Richard, Jackson, April and Catherine tackle a tough trauma case intensified by hospital politics; Amelia finally faces her feelings about Owen; Meredith gets caught between Nathan and Alex over a patient.
When a young boy disappears from his home in St. Louis, the team examines a similar cold case for clues.
A dangerous patient escapes the hospital room, putting the doctors' lives at risk; Alex faces a difficult decision in his relationship with Jo; Meredith has big news for Nathan.
April and Andrew consult with a patient who has an inoperable heart tumor; Alex and Eliza disagree about the treatment of a young patient; Stephanie and Ben make major decisions.
Believing jail time awaits him, Alex makes an important decision about his future; the hospital treats victims of a building collapse; Richard wants answers about Eliza's presence at Grey Sloan.