A political pollster's predictions uncharacteristically fail as he becomes the next person of interest; a direct order from Moreno sidelines Reese.
Michael's medical condition forces him to go to the hospital; Lincoln and Sucre get into an explosive situation; Agent Self meets with a shocking ally.
Michael comes face to face with the general and is betrayed by one of his own as the search for Scylla reaches its shocking end.
Michael, Lincoln and Sucre have to crash a police benefit to get the next card key; Sarah falls back into an old habit; on his first day of his new job, T-Bag runs into some old friends and arouses suspicion.
Michael and his crew make their final preparations for the break-in to steal Scylla; Gretchen uses her feminine wiles to obtain the final card key from the general (Leon Russom); T-bag reaches the point of no return.