Several of the doctors compete to be the new face of Seattle Grace; April brings an emergency case to the hospital; Alex and Jackson work with a transgender teen couple; new policies test the patience of the staff.
The team investigate the disappearance of three children from a bike path, the location of a similar unsolved disappearance that took place 30 years ago.
Shocking secrets come to light during an interrogation; the terrorists threaten to escalate the magnitude of their attack.
While investigating the murder of a young woman, Castle and Beckett find evidence that links her death with Senator William H Bracken, the man responsible for Beckett's mother's murder.