While Elizabeth is in Libya to help negotiate an end to its civil war, a tragic accident with her chauffeured car embroils her in an urgent situation to secure medical care for a gravely wounded local girl.
Secretary of State McCord must negotiate an agreement to prevent a government shutdown; it is proving difficult to find a suitable replacement for the chief of staff position.
Elizabeth is determined to hold a human trafficking conference in Kyrgyzstan. Elizabeth and Henry worry about Alison when she keeps coming home from college.
McCord and her staff work to extradite a Mexican cartel leader to a U.S. prison to diminish the opioid crisis. The cartel leader escapes and an urgent search is undertaken.
The president and Elizabeth refuse to negotiate with terrorists for the release of a captured CIA agent; Henry disagrees with them; Elizabeth tries to support Stevie through a difficult time.