Winston Story

Derek searches for the best way to propose to Meredith; Callie tries to convince Mark not to blow his chance at real love with Lexie, despite his fear of Derek finding out; Izzie learns she has anemia.

Cristina tells Alex and Bailey about Izzie's condition; Mark is doing a face transplant on a patient and Owen and Alex are the donor gathering team; Bailey sends Callie after Derek to bring him back and Callie ends up staying in his vortex of self-pity.

Addison, Naomi and Sam rush Archer to Seattle Grace to try and save his life; Owen runs into a significant someone from his past; Izzie employs her fellow doctors in a medical game to teach the interns.

A group of college students are rushed to Seattle Grace following a serious car crash on their way to the graduation ceremonies; Izzie continues feeling similar symptoms.

Izzie returns to work while the Seattle Grace residents fear possible layoffs; Bailey and Alex's difficult case is further complicated by her schizophrenic son.

Major Owen Hunt returns to be the head of ER trauma; Meredith finds an old doll her mother gave her when she was 5.