Mac Brandt

Cristina, back from her honeymoon trip, searches in vain for Burke; Meredith, Cristina, Izzie and Alex spend their first day as residents with their own groups of interns.

Derek and Meredith get ready for their wedding; college students injured in a car accident are admitted to the ER; Izzie starts experiencing familiar symptoms.

"Grey's Anatomy's" three-episode story arc continues with a part two that will challenge the interns of Seattle Grace -- and "Grey's" fans as well -- like never before.

While undergoing aggressive cancer treatment, Izzie focuses on planning Meredith and Derek's wedding; Callie's father visits; Owen seeks help with his PTSD.

Kellerman and Hale pay a visit to Warden Pope, whose past may not be as angelic as it appears. Meanwhile, Michael learns he may be getting out of Fox River much sooner than he expected – without Lincoln. Outside the walls, Veronica and Nick's investigation to prove Lincoln's innocence gives her doubts of her own.

DiNozzo remembers his time in the Baltimore Police Department when he chases a suspect from a 15-year-old case.