This sequel follows police Detective Michael Dooley (James Belushi) and his faithful German shepherd partner, Jerry Lee, who have been working together for 10 years. For Jerry Lee, this means that the canine is quite old, and has a hard time keeping up with police duties. Joining the pair is fellow officer Wendy Welles (Christine Tucci) and her tough Doberman pinscher. Together, Dooley, Welles and their respective dogs attempt to track down a gun-wielding psychopath.