While training with a mysterious covert ops group known as the Sisters of the Hood, Red (Hayden Panettiere) gets an urgent call from Nicky Flippers (David Ogden Stiers), head of the top-secret Happily Ever After Agency. A wicked witch (Joan Cusack) has kidnapped Hansel (Bill Hader) and Gretel (Amy Poehler), and Red's the only one who can save them. Accompanied by the Big Bad Wolf (Patrick Warburton) and Wolf's pal, Twitchy (Cory Edwards), Red sets out to bring the children back.