Barbara Streisand and Ryan O'Neal star in a screwball romantic comedythat races across San Francisco in What's Up, Doc?Carefree, eccentric Judy Maxwell (Streisand) has a suitcase with anencyclopedia and a nightgown--and eyes for repressed, eccentric HowardBannister (O'Neal). Howard has a suitcase full of igneous rocks to provean esoteric musical theory and an overly proper fiancée named Eunice(Madeline Kahn). None of them know Mr. Smith (Michael Murphy), who has asuitcase full of top-secret government documents and a nefarious mantailing him.Add another suitcase full of jewels, a crooked hotel detective and ajealous musicologist. Put them all together in the same hotel. Jugglethe suitcases ... and watch the laughs fly!