Patrick Jane, Lisbon and the CBI team brace themselves to finally meet their new boss, Special Agent Madeleine Hightower (Recurring guest star Aunjanue Ellis – True Blood).
When a police officer's daughter is kidnapped, Jane and the team must race to find the girl.
A student from an elite prep school is murdered; Lindsay returns to Montana to visit her dad and face past issues.
The doctors are exposed to flu-infected patients; Derek prepares to give a speech; a new doctor gives Alex a glimpse into an alternative medical practice.
Cristina won't let herself get excited when she is nominated for a Harper Avery award; Alex thinks about making a change; Callie and Derek work with a machine that recognizes emotions.