Ten years after the animals have been cured, a new threat rises in the form of "the hybrids," an army of unstoppable lab-made creatures focused on destroying mankind.
Logan and Jackson find a link between hybrid attacks; Mitch is questioned by a woman who claims to be Clementine; a new development in Abraham's research puts his family in danger.
Daniela and Abraham think about making a deal with Reiden Global; Clementine and Jamie perform a dangerous surgery on Mitch.
The team comes together on the island of Pangaea to put the final pieces of the cure in place.
While Jamie is under arrest, she manages to manipulate Mitch and Logan into helping her hunt shepherds, members of a secretive group responsible for sterilizing humans.
