Born Judith Therese Evans in Livonia, MI, Greer was raised the daughter of a mechanical engineer and a hospital administrator. She attended Winston Churchill High School, where she later admitted that her social status went from not being noticed to not caring at all. The self-proclaimed former ugly duckling trained for almost 10 years in Russian ballet before entering the prestigious theater program at DePaul University, where she graduated in 1997. Just three days after graduation, she landed a small part in the romantic comedy "Kissing a Fool" (1998) with Jason Lee and David Schwimmer. The one-time telemarketer and oyster shucker flew to Los Angeles for the movie premiere and ended up staying. Greer next joined the cast of "Jawbreaker" (1999), a dark comedy that focused on a popular clique of girls who accidentally kill their best friend. That same year, Greer found herself locking lips with George Clooney in the opening scene of "Three Kings," and followed with notable turns in romantic comedies "What Women Want" (2000) and "The Wedding Planner" (2001). Even though she had landed only supporting roles up until this time, Greer caught the eye of producers and managed to gain a foothold on everyone's list for essaying unexpectedly scene-stealing characters. She next played the waitress who becomes the object of Charlie Kaufman's obsession in the Academy Award-winning film "Adaptation" (2002), and made the successful transition to the small screen when she joined the cast of "Arrested Development" (Fox, 2003-06) in the recurring role of secretary Kitty Sanchez. After playing the backstabbing best friend of Jennifer Gardner in "13 Going on 30" (2004), she appeared on other series like "Love and Money" (CBS, 1999), "CSI: Miami" (2002-2012), "Two and a Half Men" (CBS, 2003-2014) and "Californication" (Showtime, 2007-2014). Greer also earned wide praise for her hilarious portrayal of a circus performer in a 2006 episode of "My Name Is Earl" (NBC, 2005-09), which helped open the doors to more opportunities in a wider array of genres.Throughout her career, Greer also stretched her dramatic muscles by scoring parts in non-comedic films and independent projects. She starred opposite Sigourney Weaver, Joaquin Phoenix and Adrien Brody in M. Night Shyamalan's supernatural thriller "The Village" (2004) before appearing in Wes Craven's werewolf horror flick "Cursed" (2005). That same year, Greer acted in "Elizabethtown" as Orlando Bloom's sister and Susan Sarandon's daughter in writer-director Cameron Crowe's romantic comedy-drama. Following turns in Paul Weitz's political satire "American Dreamz" (2006) and the indie comedy "The Amateurs" (2006), Greer starred on the short-lived sitcom "Miss Guided" (ABC, 2008), which lasted a scant seven episodes before being cancelled. Her next series, the animated spy comedy "Archer" (FX 2009-), on which she played independently wealthy secretary Cheryl Tunt, was far more critically and commercially successful. She starred alongside Katherine Heigl and James Marsden in the romantic comedy "27 Dresses" (2008), played a friend and employee to Jennifer Aniston in "Love Happens" (2009), and performed in the live-action film "Marmaduke" (2010). On the small screen, she joined Ashton Kutcher in a recurring role as his wife on "Two and a Half Men" (CBS, 2003-2014) when the actor replaced an outgoing Charlie Sheen. After co-starring opposite George Clooney in Alexander Payne's acclaimed comedy-drama "The Descendants" (2011), Greer next co-starred in the Duplass brothers comedy-drama "Jeff, Who Lives At Home" (2011) and the Gerard Butler romantic comedy "Playing For Keeps" (2012). Returning to darker roles, Greer co-starred in Kimberley Peirce's remake of the horror classic "Carrie" (2013), psychological thriller "Jamie Marks Is Dead" (2014), and action sequel "Dawn of the Planet of the Apes" (2014). Alongside her continuing work on "Archer," Greer starred in the dark sitcom "Married" (FX 2014-15) opposite Nat Faxon, co-writer of "The Descendants." Along with co-starring in Jason Reitman's "Men, Women & Children" (2014) and Paul Weitz's "Grandma" (2015), Greer appeared in several big-budget summer films in 2015, including Brad Bird's fantasy "Tomorrowland" (2015), the Marvel film "Ant-Man" (2015) and the franchise reboot "Jurassic World" (2015). She also returned to her indie roots with the comedy-drama "Ordinary World" (2016), starring Green Day frontman Billie Joe Armstrong, Brett Gelman's Lemon" (2017), and "Wilson" (2017), based on the Daniel Clowes graphic novel, After making her directorial debut with "A Happening of Monumental Proportions" (2017), Greer took on a motion capture role in the hit sequel "War for the Planet of the Apes" (2017) and starred in the indie romance "Our Souls at Night" (2017), teen comedy "Adventures in Public School" (2017) and indie comedy "Pottersville" (2017). Veering back toward the mainstream, Greer appeared in Clint Eastwood's docudrama "The 15:17 to Paris" (2018), reprised her role in "Ant-Man and the Wasp" (2018) and played the daughter of Jamie Lee Curtis' Laurie Strode in David Gordon Green's "Halloween" (2018), During this period, she also co-starred in the Jim Carrey comedy-drama "Kidding" (HBO 2018-) and co-starred in indie drama "Measure of a Man" (2018).