When a homeless teenager's (Bridgit Mendler) symptoms get worse, adult consent is required for an invasive surgery; Taub tries to connect with his daughters; House threatens Foreman's relationship with a married woman (Yaya DaCosta).
An out-of-this-world case brings Brennan and Booth to New Mexico where they investigate human remains with extraterrestrial attributes. The victim is identified as a local UFO fanatic, known around town for her relentless search for alien life forms and whose latest “evidence” leads even Brennan and Booth to re-think outside existence. Meanwhile, a local sheriff refuses to release the bones, forcing the team at the Jeffersonian to work via satellite, and Angela and Jeffersonian intern Wendell (guest star Michael Grant Terry) come clean about their relationship.
The team investigates the death of a petty officer and discovers he may have been leading a violent secret life.
Castle is captured and forced to work with strangers to solve deranged puzzles and mind games, while Beckett races to rescue him.
Michael and Sam continue the hunt for Maxi's killer; Jesse, Fiona and Michael help a scientist recover a revolutionary formula from his greedy and duplicitous former business partner.
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