A man is killed after winning a fortune and then dumping his girlfriend. So, Grissom, Nick, and newcomer to the CSI team, Sara Sidle, investigate this one.
When a teenager and her sister are the sole survivors of the gruesome murder of four members of one family in a quiet suburban neighborhood, Grissom and his entire team investigate the crime.
The entire CSI team investigates a disappearance at a local university.
The team is investigating the ongoing murders by a signature killer. The killer has some knowledge of forensics and has left little evidence behind.
Grissom and his team investigate a murder suspect who is caught red-handed, burying the victims, while Catherine and Warrick take on the case of a woman found dead in a hotel spa.