Jay takes Manny out to cut down their own Christmas tree. Gloria is on edge with mum in town, but changes her tune when she sees her bonding with Claire.
Richard's 10,000th surgery is a liver transplant for two sisters; Derek and Lexie take on a case that had been declared inoperable; Teddy and Cristina try to swipe a case from Alex and Dr. McQueen; Meredith tries to choose a specialty.
When word spreads that Lorelai was the one who proposed, Luke is embarrassed; Lorelai, still angry at Rory for dropping out, tells Emily and Richard that they can care for her now.
Veridian Dynamics tries to match employees based on their genetic compatibility; Linda and Ted find themselves instantly attracted to their supposed matches.
Callie and Arizona's wedding is not coming together as they hoped it would; Alex seems to be the first choice for chief resident; Meredith and Derek make a life-changing decision; Dr. Perkins tempts Teddy with a proposition.