The BAU travels to San Francisco to investigate the murders of several homeless men and teams up with a separate group of BAU operatives.
Susan's longtime book agent and dear friend, Lonny Moon (Wallace Shawn), gets into financial trouble; Bree reburies Rex amid police suspicions.
Lynette tries to put a day-care center in Parcher & Murphy but, first, must convince the boss's neurotic wife, Fran (Penelope Ann Miller), to leave her baby.
Alan and Denny take the case of an unscrupulous attorney accused of obstructing justice on behalf of his brother; Denny practices the power of positive thinking in hope of getting Raquel Welch into his life.
A bizarre occurrence at the infamous "Area 51" swaps Mulder's consciousness with that of a stranger.