In the face of natural disasters, supernatural creatures, and a horrifying plague, the Copeland Family fights to survive the end of the world.

The Copelands continue their quest to find their daughter.

The Copelands meet the only man with the cure to the plague.

A horde of vicious feverheads and flesh-eating parasites trap the Copelands at a plague isolation unit.

After accepting help from an old friend, Karen is tormented by a harbinger of death, and the Copelands learn that no refuge is truly safe.

When the family splits up, Josh leads half the party to a nearby university, while Karen leads the others to a nearby summer camp.