Charlie, a baseball player with anger issues decides to return to therapy after a bad run-in with his ex-wife's new boyfriend.

The new Charlie deals with a ghost from his baseball-playing days when an unattractive woman he slept with shows up as a new patient.

Charlie conducts a sleep deprivation experiment on his group, which yields some very surprising results for everyone--including Charlie.

A long-standing rivalry over who's a better therapist leads to war when Kate steals Patrick, one of Charlie's group patients.

Charlie wants to "date" his ex's cute, new business partner. She believes in ghosts but not in therapy.

Charlie starts covertly dating a brilliant coffee-shop barista who is a patient of Kate's.