In an unexpected twist of fate April lands in the hospital where her estranged uncle George (Steven Weber) works as an oncologist and she learns the devastating news that she has cancer.

A new assignment to profile gubernatorial candidate Bruce Hendrie leads to an unexpected run-in with his son Leo (Scott Michael Foster). April makes a startling discovery about her family while Sara struggles with solo parenting.

As things begin to heat up with Dominic April second-guesses the status of their relationship when she learns he has a reputation as the office playboy. To help take her mind off of Dominic and to start facing the reality of her symptoms she volunteers for an assignment at work about a supposed cancer-curing miracle juice and finds a confidant and support in the juice maker Gerald (guest star Sam Anderson). Meanwhile Sara makes a surprise connection with one of her therapy patients and hosts an awkward dinner for her new boyfriend Ben to meet the family.

April finds it harder to juggle the increasing severity of her symptoms with her obligations at work and her attempts to be a supportive daughter and sister. After missing an important appointment George urges April to get her priorities straight. April also learns more about Leo Hendrie but Leo jumps to conclusions about April's motives. Meanwhile much to her own surprise Brenna bonds with Greer a popular girl at school.

Dominic takes April to see a psychic for fun but the results disturb both of them leading Dominic to come clean to April about a family secret. When her own family secrets become too much for her to bear alone April enlists Dominic's help in learning more about her "sister" Natalie.Meanwhile April receives an official diagnosis from George and Sara's mounting concern for April's health leads to a confrontation.

April gets a surprising invite to shadow Bruce Hendrie at his campaign ad shoot for the paper. While there Leo senses her apprehension of her diagnosis and challenges April to take control of her future. Not one to back down from a challenge April accepts and gets a taste of Leo's reckless and carefree life. But when things go too far she learns the severity of Leo's illness. Meanwhile Brenna is unsure of her future with Kiernan even more so when the relationship causes tension with her new friend Greer.