The series premiere takes Zane Lamprey to Phoenix, Arizona. He meets an illegal tequila moonshiner, makes a monster margarita and invents the ranch dressing beer-bomb.

Zane visits Santa Fe, New Mexico, where he meets a master margarita maker, drinks a beer that can kill chickens and eats some of the hottest chili pepper sauce in the state.

Zane rolls into Austin, Texas, where he infuses vodka with fruit, drinks the hottest bloody mary in town and tries his hand at an Austin tradition, spiking a watermelon.

Zane visits Dallas, Texas, where he mixes a spicy margarita, tries some of Mama's mixes in a Double Wide and gives his competition the boot at Dallas Cowboy Stadium.

Zane drinks his way through the Big Easy. He suffers a brain freeze at Lafitte's Blacksmith Bar Shop, the oldest bar in the U.S., he tries a hand grenade, supposedly the strongest drink in NOLA, and faces down a Hurricane at the world famous Pat O'Brien's.

Zane hits Miami Beach, Florida, where it's time for some fun in the sun. He makes 40 mojitos in a minute at Lario's on the Beach, taps a cask of ale at premier beer bar Red Light Red Light and tries to cool off with liquid nitrogen at the Ritz-Carlton, South Beach.