Good Sam focuses on Dr. Samantha Griffith (Sophia Bush) as she learns the ropes as the new top surgeon at Lakeshore Sentinel Hospital, a role she’s had ever since the legendary leader of the place — her father (Jason Isaacs) — fell into a coma. But complications have set in: Having recovered, the elder doc wants to resume his duties. Sam can only relent, right? The result is a clash of family wills between old guard and new methods in a life-and-death business.