Peter Romancek, a young man and his mother move to the town of Hemlock Grove that gets in alert after a young girl's body is found and the strange rumours about Peter's nature lead the townsfolk to suspect him.

Roman Godfrey confronts Peter who was investigating the scene of the crime by himself and the two become friends, with Peter sharing his secret with him. Meanwhile, Roman's cousin Letha discovers that she is pregnant, but claims that the child's father is an angel.

Christina discovers a new victim; Sherriff Sworn gets outside help from Dr. Chasseur; now a suspect, Peter joins Roman to find the killer.

Letha's interest in Peter takes a turn; Chasseur and Sworn's investigation hits a new low; Roman and Peter are a step ahead.

Shelley's connection to Dr. Pryce is further revealed; Destiny helps Peter understand the recent murder; the gala at the Tower goes horribly awry.

Peter and Roman follow Lisa Willoughby's trail to the old steel mill where they find a missing piece of the puzzle; Christina's date goes poorly.