Wowzers! Just when you thought the world was safe from MAD, the supremely evil Dr Claw is,unfrozen from his iceberg prison, and he hasn’t changed a bit – he still wants to defeat Gadget,and HQ! However, he’s missing his signature Claw, which throws him off his game, and Gadget,has retired. What’s an evil genius to do?

Dr Claw has a plan to take over the hi-tech communications array at the top of the Towering,Towers, the tallest skyscrapers in the world, before the Towers’ grand opening. AND Something mysterious is going on in low-Earth orbit – astronauts are disappearing from the Multinational Space Station! Chief Quimby sends Gadget and Penny off to investigate.

OMG! International whistling pop star Nigel Saint De La Peppertone the Fourth Esquire the Third is coming to town, and Penny is vibrating with excitement! And so is Dr Claw, but he is interested in Nigel for more nefarious purposes – that is, bringing the Nigel Army under his control! AND Professor Von Slickstein is due to present his latest top-secret invention at the upcoming tech-related fashion show in Paris, with Gadget as his chaperone/bodyguard.

Dr Claw has made a new recruitment video for MAD agents, but Talon thinks it’s a little….well….LAME! He tells his Uncle that some star power is needed, and kidnaps international action star Tag Shrapnel to use in the most awesome recruitment video/indie movie EVER!! AND Go Go Gadget Chewable Vitamins! The world’s greatest detective, Inspector Gadget, is down with the world’s worst case of the flu, and it is up to Penny to apprehend the world’s greatest,art thief.

Me-ow-ark! Dr Claw has disguised MADcat as the world’s oddest dog in an attempt to hypnotize and enslave the world’s dogs, starting at the prestigious Dog and Boney show. Gadget is sent in undercover as a Dog Show judge, a job he takes a little too seriously. AND Dr Claw has created a serum capable of turning harmless apples into vicious, JUICY monsters! Chief Quimby gets wind of it and dispatches Gadget and Penny to investigate.

Gadget and company infiltrate a vacuum cleaner convention to stop MAD from aquiring the Suckatron 3000, the most powerful vacuum cleaner in the world./Talon, intent on proving himself to his uncle, breaks into Claw Manor to steal Dr. Claw's training claw, setting off alarms in HQ that lead Gadget, Penny and Brain to race Talon to find the missing artifact.