Weaving together the stories of five of America's most notorious serial killers: Ted Bundy, John Wayne Gacy, Jeffrey Dahmer, the Green River Killer and BTK.

In the mid-to-late 1970s, Bundy, Gacy and BTK begin claiming victims, while Dahmer and the Green River Killer inch ever closer to realizing their grim fantasies.

With their confidence growing in 1978, Bundy, Gacy, Dahmer, the Green River Killer, and BTK continue their game of cat and mouse with law enforcement; Gacy and Bundy are finally brought to justice; Dahmer struggles to resist his murderous urges.

After years of evading capture, Gacy and Bundy are finally brought to justice as they both face punishment for their heinous crimes.

Two of The Five, Gacy and Bundy, sit on death row in the mid-1980s as their murderous rampages are curtailed.

After years of public fear at the hands of The Five, the remaining three killers are captured between 1991-2005.