Weaving together the stories of five of America's most notorious serial killers: Ted Bundy, John Wayne Gacy, Jeffrey Dahmer, the Green River Killer and BTK.

In the mid-to-late 1970s, Bundy, Gacy and BTK begin claiming victims, while Dahmer and the Green River Killer inch ever closer to realizing their grim fantasies.

In the mid-1980s, Gacy and Bundy sit on death row; BTK kills his own neighbor; Dahmer succumbs to his devious fantasies and commits his most heinous crimes to date; the remaining three killers are captured between 1991-2005.

In 1978, Bundy, Gacy, Dahmer, the Green River Killer and BTK continue their cat-and-mouse game with law enforcement.

In the mid-1980s, Gacy and Bundy are on death row, while their killings have finally stopped.

After years of terror, the Green River Killer, BTK and Jeffrey Dahmer are captured between 1991 and 2005.