Xiao Yan (Yang Mi), a skilled EICU doctor who recently returned from abroad, struggles to settle into her new role at Tongshan Hospital while dealing with personal grief from losing her fiancé. Her cold exterior makes connecting with colleagues challenging, especially when working alongside the initially arrogant Bai Shu (Bai Yu). As they collaborate on challenging medical cases, Bai Shu's perspective shifts after adopting a terminally ill patient, softening his previously inflated ego. The two doctors gradually develop a deeper understanding of each other while working intensely to save patients' lives. Their professional partnership begins to reveal unexpected personal connections, hinting at a potential deeper relationship. Based on the novel "ICU 48 Hours" by Seng Li, this is a 2022 Chinese medical romance drama directed by Zhang Rui.