Pinky and The Brain go undersea in a submarine to find the key ingredient for a hypnotic pancake batter.

The Brain gets a job at a large corporation and schemes to collect workmen's compensation in order to fund another plan to take over the world.

In Tokyo in the 1950s, The Brain reverses a miniaturization ray to create monsters to scare the city and then rescue it. Trouble occurs when a real monster arrives.

In the 1930s, The Brain poses as The Fog and plots to broadcast his hypnotic voice over the radio./Pinky and The Brain alter the inscription on a space probe to show themselves as the dominant species.

To fund their latest scheme, Pinky and The Brain establish a bogus country in order to receive massive foreign aid from the United States.

The Brain decides he will take over the world by starring in a hit TV sitcom, but his dreams of fame and global dominance get shattered.