A case turns personal for Pride when the body of a Petty Officer is identified as a former gang member he once mentored. Meanwhile, Brody continues her search for the perfect place to call home in New Orleans. David McCallum guest stars as Doctor Donald "Ducky" Mallard; Steven Weber guest stars as Councilman Douglas Hamilton; and James McDaniel guest stars as Papa Parks.

When a Navy lieutenant on liberty dies of bubonic plague, NCIS Special Agent Tony DiNozzo helps the New Orleans team as they try to control a potential outbreak and find the source of the infectious disease.

An armored transport bus crashes, resulting in the escape of four prisoners -- including a black market broker topping the list of national security threats; Pride needs Gibbs' help with a case file full of redactions.

When a Navy SEAL is found dead in a sorority house, the team must determine if his death was related to collegiate foul play or a classified mission; Pride's daughter visits the office.

The investigation into a chief warrant officer's death reveals that his wife has been abducted -- leaving the team with a 22-hour deadline; senior FBI agent Fornell assists with the case.

Amidst Halloween festivities in New Orleans, a Naval Staff Judge Advocate dressed in a costume is found dead in a cemetery; the team debates Halloween costumes and activities.