In a world where having powers can make you a celebrity, the death of a well-known superhero is headline news. Now Detective Christian Walker (Sharlto Copley) and his new partner Deena Pilgrim (Susan Heyward) are on a mission to discover the truth, leading them to Calista (Olesya Rulin), a young woman with a mysterious past and suspicious motives.

Conflicted with the loss of his former life as a Power, power-less Detective Walker (Sharlto Copley) must overcome his personal demons and find Calista (Olesya Rulin) who has gone missing. Now with the reappearance of old friend turned foe Johnny Royalle (Noah Taylor), Walker is left with more questions than answers.

As a lethal powers-enhancing drug is unleashed on the public, Detectives Walker (Sharlto Copley) and Pilgrim (Susan Heyward) seek out the criminal mastermind behind it with the help of iconic Power, Retro Girl (Michelle Forbes). As clues come to light, Walker considers the possibility that Wolfe (Eddie Izzard), his dangerous former mentor turned nemesis, might have the answers he seeks.

Walker (Sharlto Copley), Pilgrim (Susan Heyward) and the rest of the Powers Division must prevent Wolfe (Eddie Izzard) from escaping the high-security prison that holds him, The Shaft. As Wolfe goes on a murderous rampage from within the prison, the Powers team is forced to try a new top-secret technology to keep him detained – code name: The Drainer.

As Retro Girl (Michelle Forbes), Zora (Logan Browning) and the heroes of the world rush to stop the escape of Wolfe (Eddie Izzard) from The Shaft, Walker (Sharlto Copley) realizes he must face him alone, the inevitable clash between mentor and disciple that will unravel the deep-seated history between them.

In the wake of the battle to stop Wolfe (Eddie Izzard), the Powers division gathers to mourn the loss of their fellow officers, while Walker (Sharlto Copley) seeks answers about his own future and the possibility of becoming Diamond once again. After seeing the uncertain and dangerous side effects of Sway first-hand Johnny Royalle (Noah Taylor) begins unsavory experiments on known subjects of the drug.