Claire discovers signs reminiscent of Raccoon City; Leon makes his way to the White House.

Leon, along with agents Jason and Shen May, embarks on a covert mission to infiltrate a research facility in Shanghai aboard a nuclear submarine.

Claire discovers a grim scene at the home of one of the last surviving members of the Med Dogs Unit; Shen May warns Leon about an ominous conspiracy.

Secretary Wilson threatens Claire's life, demanding that she drop her investigation; Leon and Shen May rush to the vast subterranean bio-weapons lab.