A new generation of young cartoon characters attends Acme Acres Looniversity, where they embark on a series of off-the-wall adventures while learning the basics of comedy from their Looney Tunes mentors. Popular characters include Buster Bunny, Babs Bunny, Plucky Duck, Hamton J. Pig, Fifi La Fume, Dizzy Devil, Calamity Coyote, Sweetie Bird, and two human characters, Elmyra Duff and Montana Max, who are regarded as the main villains of the series.