When Romain (Melvil Poupaud), a vain young photographer, is diagnosed with a virtually inoperable brain tumor, he refuses treatment and tells no one of the prognosis. Romain recoils from his partner, Sasha (Christian Sengewald), but confides in his worldly grandmother, Laura (Jeanne Moreau), who encourages him to reexamine himself before he departs the world of the living. Soon Romain meets Jany (Valeria Bruni-Tedeschi), a waitress who offers him a surprising opportunity to die meaningfully.