Joyce Guy

An outbreak of a sexually transmitted disease affects several members of the hospital staff, prompting Chief Webber to call a meeting. Meanwhile, the chief reluctantly confides to Dr. (Derek) Shepherd about his own medical concerns; Izzie and Cristina are worried by a patient's wife and daughter who are at odds over his care; Burke treats Bill, a college buddy whose medical diagnosis raises some questions regarding his wife's actions; and, just as Meredith and Derek grow more intimate, a bombshell is dropped.

Izzie seems to be getting over Alex when she shares an undeniable chemistry with Denny Duquette, a patient who's awaiting a heart transplant, and George treats Bex, a young teen hermaphrodite.

The race for the Chief's position is on, as the doctors compete for Richard's affections, a surgical patient endangers the lives of those around her, and Meredith's Alzheimer's-stricken mother, Ellis, experiences a change in her medical condition.

Lisbon and Jane attempt to start their lives together but a killer's quest for revenge puts Lisbon and Jane's happiness in jeopardy.

When Deke (recurring guest star ERIC ANDRÉ) invites Max and Caroline to join him and his parents for dinner at their home, Max is tongue-tied - until his mother confides in her about her secret past. Guest stars Jeff Garlin (Curb Your Enthusiasm, Arrested Development, The Goldbergs) and Sheryl Lee Ralph (Moesha, Instant Mom, It's a Living) guest star as Deke's parents.

When a corpse is found at a landfill, dyed in a blue substance, intern Arastoo Vaziri (guest star Pej Vahdat) discovers a method that helps eliminate postmortem damages to the corpse, which leads the team back to a hair salon where the victim worked. Meanwhile Bones is feeling uncomfortable in her post-baby body, so Booth decides to do something special to boost her self-confidence.