Joyce Guy

In an attempt to make up for her slow massage business, Phoebe takes a job as a telemarketer for an office supply company. When her first call is to a despondent office manager, she takes it upon herself to convince him to not kill himself. Monica and Ross discover that their parents are selling their house. When they go to collect their stuff, they find that Mr. Gellar used Monica's boxes to stop flood water from getting to his Porche and all her things are ruined. While attempting to re-arrange the furniture, Rachel breaks Joey's favorite chair (that he's named Rosita).

Izzie seems to be getting over Alex when she shares an undeniable chemistry with Denny Duquette, a patient who's awaiting a heart transplant, and George treats Bex, a young teen hermaphrodite.

An outbreak of a sexually transmitted disease affects several members of the hospital staff, prompting Chief Webber to call a meeting. Meanwhile, the chief reluctantly confides to Dr. (Derek) Shepherd about his own medical concerns; Izzie and Cristina are worried by a patient's wife and daughter who are at odds over his care; Burke treats Bill, a college buddy whose medical diagnosis raises some questions regarding his wife's actions; and, just as Meredith and Derek grow more intimate, a bombshell is dropped.

The race for the Chief's position is on, as the doctors compete for Richard's affections, a surgical patient endangers the lives of those around her, and Meredith's Alzheimer's-stricken mother, Ellis, experiences a change in her medical condition.

Lisbon and Jane attempt to start their lives together but a killer's quest for revenge puts Lisbon and Jane's happiness in jeopardy.

When Deke (recurring guest star ERIC ANDRÉ) invites Max and Caroline to join him and his parents for dinner at their home, Max is tongue-tied - until his mother confides in her about her secret past. Guest stars Jeff Garlin (Curb Your Enthusiasm, Arrested Development, The Goldbergs) and Sheryl Lee Ralph (Moesha, Instant Mom, It's a Living) guest star as Deke's parents.