Eight days before his 50th birthday, ultra-runner Kevin Kline set out to run the final 300 miles above the Arctic Circle on Alaska's dangerous Dalton Highway, in winter, for childhood cancer awareness. If successful, Kline would be the first recorded person in history to accomplish the feat. Traversing the world's tenth most dangerous road, Kline and his crew face a hostile environment of -40F temperatures on an ice road in the dark to run a 9lb backpack full of childhood cancer names to the virtual top of the world. When the unexpected happens, the crew is faced with a mission-changing dilemma.