In the fifth season premiere episode, Sheldon (IAIN ARMITAGE) and Missy both run away from home, while Mary (ZOE PERRY) gets some upsetting news about George Sr. (LANCE BARBER).
While Sheldon tries to convince Dr. Sturgis (recurring guest star WALLACE SHAWN) to return to the university, Georgie upsets the family when he makes a life-changing decision.
Dale and Meemaw work out relationship issues while playing Dungeons and Dragons with Sheldon and Missy. Meanwhile, Mary and George take a trip with Coach Wilkins (recurring guest star DOC FARROW) and his wife; and Georgie freaks out when his girlfriend thinks she’s pregnant.
George and Meemaw struggle to manage the Cooper household while Mary plans Pastor Jeff's wedding.
Dr. Sturgis is furious when Sheldon accuses him of plagiarism. Also Mary sets out to find a “girl trophy” for Missy’s end-of-season baseball ceremony and Georgie has an awkward run-in with Veronica while on a date with his new girlfriend Jana (guest star AVA ALLAN). LOUIE ANDERSON guest stars as Ralph a trophy store employee.