After a long wait, Conrad and Nic prepare for their wedding day; flashbacks to the early days of the COVID-19 crisis shine a light on the heroism of the doctors and the toll the virus took on everyone at Chastain Memorial.
Cain feels disrespected by Logan Kim when he is left out of a major decision regarding Conrad; the doctors work together to try to save the lives of two big Red Rock donors who were involved in a jet skiing accident.
Conrad treats one of Gigi's fellow classmates whose stomachache turns into something much more serious; Devon takes several interns to a senior living facility; Leela uncovers some unsettling news.
When the first day of Kit's experimental Flight Go team program sends Conrad out into the field, he builds a new relationship with a fellow doctor along for the ride; Devon works with Trevor on a patient with a mysterious fever.
A tragic accident occurs at Jessica's sister's gender reveal party, putting her brother-in-law's life in jeopardy; Conrad, Irving and Trevor work on an influencer whose life was put in danger by a risky cosmetic surgery.