While Sheldon settles a score with his nemesis, Star Trek: The Next Generation's Wil Wheaton (guest starring as himself), Wolowitz begs Leonard to get Penny to set him up with one of her friends.
Leonard realizes he's the only one without a girlfriend, while Sheldon wants to get rid of his.
Amy finds she has sexual feelings for Penny's ex, Zack (guest star BRIAN THOMAS SMITH) while Koothrappali and Wolowitz try to prove who would be the better superhero.
An embarrassing secret of Wolowitz's comes to light, while Sheldon and Raj have a small war at work. Battlestar Galactica's KATEE SACKHOFF and Star Trek's GEORGE TAKEI guest star as themselves as Wolowitz's love gurus. MELISSA RAUCH reprises her role as Howard's girlfriend, Bernadette.
Penny asks Leonard to lie to her father, Wyatt (guest star KEITH CARRADINE), while Howard, Raj and Bernadette pull an all-nighter at a telescope.