Detective Sherlock Holmes investigates a home invasion that led to murder.

When a man is shot and killed while entering his apartment, Sherlock investigates; Watson goes to dinner with her ex-boyfriend.

Sherlock and Watson investigate a child abduction case involving a serial killer known as "The Balloon Man."

Holmes consults on a case involving a Wall Street executive who seems to have died from a heroin overdose; Holmes encourages Watson to start dating again.

Sherlock tracks the person who has been killing terminal patients at a hospital but making it look like they died of natural causes; more information on Watson's decision to end her surgical career is revealed.

After a small plane crashes, Sherlock tries to prove that one of the victims was already dead before the plane went down; Watson thinks Sherlock should get together with his elusive father.