Danny considers taking a new, more profitable job after investigating the death of a wealthy man; Nicky tries to avoid involving her family when she is sexually harassed by her boss at her new internship.
A man living a double life with two separate families is murdered; Erin asks Anthony to help investigate his former partner; Frank deliberates between two candidates for the chief of transit position.
Conrad takes Trevor under his wing to care for a patient whose good luck seems to have run out; Leela struggles when given the decision to take full responsibility of her indecisive patient's life.
A new group of interns, which include Billie's son, start their first day; Kit and Bell try to convince Conrad to come back to Chastain; Leela and Padma deal with an unexpected visit from their parents.
A case turns personal for Conrad when the donor recipient of Nic's heart is admitted to the emergency room; Bell is faced with a devastating diagnosis that causes him to make a heartbreaking decision.