Capt. Tom Chandler and his crew set out for the Arctic with two virologists; Chandler discovers that the virologists are collecting samples of the source of a virus that has wiped out more than half of the human population while he has been at sea.
The team investigates after a group of teens discover a dead woman behind the wheel of an abandoned car in a Nevada ghost town.
Chandler and his crew head to the U.S. military base in Guantanamo Bay in search of food, medical supplies and fuel; escaped prisoners attack the search teams; the teams enlist the help of a private contractor.
The ship's propulsion system suffers a catastrophic event; Chandler's leadership and ingenuity are put to the test.
Chandler and his crew return home; a warlord threatens the restoration of law and order; Chandler sets out to save his family.